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74
- Development and transcriptional logic drives sexual dimorphism of the nervous system
- Aaron Allen (Stephen Goodwin Lab)
- created sexed single cell transcriptomic atlas
- compared the brains and found unsurprisingly that dsx and fru where the biggest differences between sexes
- combined many datasets from many labs to do a dsx meta analysis
- clustered the data and there were 6 clusters that came out which corresponded to
- aDN, pCd1, pCd2, pC1, pC2m,l
- looked at which genes were most expressed in each of these clusters and there was one peak for each cluster for a specific protein
- then they did intersections of dsx and the gene and they got super specific and clean lines labeling all of the neurons in the specific subtype
- tried the same approach with fru but it was much messier because its more broadly expressed??
- clustered the data and there were 6 clusters that came out which corresponded to
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76
- A thermometer circuit for hot temperature adjusts Drosophila behavior to persistent heat
- Michael Alpert (Marco Gallio Lab)
- preprint and nature comms paper out in next week or so
- thermosensory ON responses predict imminent threat
- TPN III detects the ON response or the change in temperature (hot or cold)
- downstream of this neuron is a TLHON which primes fly behavior and leads to early turns
- TLHON tracks the rate of change of temperature
- used a 2 choice task and looked at the boundary of the cells
- flies learn over time to turn earlier and earlier away from heat
- silencing TLHONs gets rid of this early turning effect
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115
- Investigating the control of small error corrections during Drosophila pursuit behavior
- Mathew Colli (Rachel Wilson Lab)
- AOTU 19 recruited through errors to stabilize turning
- recruited during pursuit
- P1 stim enhances activity
- inhibition of AOTU19 can cause turning
- does moment to moment steering corrections
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122
- Morphological adaptations to excess activity in single Drosophila Kenyon cells
- Tom Cozens
- hyperactivity reduces claw numbers in Kenyon cells
- used MARCM to sparsely label KCs (randomly labels and hope to get just one cell alone)
- expressed TrpA1 in single KCs to make them hyperactive for a period of time
- only looking at morphological changes and saw a decrease in the dendritic claws
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128
- Persistent activation of dopaminergic neurons and its impact on behavior and neural circuitry in Drosophila Larvae
- Stephanie Dancausse
- Nicotine decreases turning in larvae
- long term recording set up looks very cool but the data collected was all very prelim
- presenter wasnt at poster so couldnt ask questions
- didnt see link to dopamine in any of the data
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154
- Dissecting social memory circuits in fruit flies
- Gulhamay Gardashova
- Dopamine neurons store social context for days
- isolated animals track better than group housed animals
- hypothesized that the neuron that stores the social memory would accumulate activity over long periods of time and store it for long periods of time in its activity
- developed a new tool to measure this called CRTC::GFP
- calcium influx activates calmodulin which phosphorylates CRTC. CRTC then enters and stays in the nucleus for a long time
- could do experiments of social interactions then take the fly and image activity of neurons later
- found that DAN in the mushroom body stores the social info and it only seems to care about touch, not vision or olfaction
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158
- Mating induced somnolence
- Ethan Glantz
- after mating females increase their time sleeping
- however starved females do not increase their sleep
- dopamine transporter important for this effect
- did a huge screen and there is lots of variability in sleep (12hr range)