channels have a narrow region called a selectivity filter. ions shed water shell and form a weak bond with polar amino acid residues in the wall of channels
the selectivity filter was first proposed by bertil hille
🥚
references
Kandel, E. R., Koester, J., Mack, S., & Siegelbaum, S. (Eds.). (2021). Principles of neural science (Sixth edition). McGraw Hill.